Saturday, March 26, 2011

Opioid Analgesics : what causes pain?

opioid analgesic

Certainly, the physician must always strive to eliminate the root cause of the pain. However, pain itself require active therapy, especially in the acute and severe cases. In current clinical practice, prevention and treatment of pain is achieved mainly through painkillers. Among the most widely used analgesics neopiatnye presented nonsteroidal anti-inflammatory drugs. However, these drugs are effective only for mild to moderate pain intensity, with the possible exception of injectable lornoksikama, ketorolac and diclofenac, which are estimated as more active. The most effective pain relievers are opiates (opium alkaloids) and their synthetic analogs - opioid analgesics.
  • Pain is caused by the stimulation of pain receptors which are free nerve endings.
“Nocireceptors are pain receptors that are located outside the spinal column in the dorsal root ganglion and are named based upon their appearance at their sensory ends. These sensory endings look like the branches of small bushes”
  • There are two types of nocireceptors that mediate fast or slow pain signals
The perception of pain is when these receptors are stimulated and they transmit signal to the central nervous system via sensory neurons in the spinal cord.

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