Analgesia simply means the absence of pain without loosing consciousness.
“The analgesia system is mediated by 3 major components : the periaquaductal grey matter (in the midbrain), the nucleus raphe magnus (in the medulla), and the pain inhibitory neurons within the dorsal horns of the spinal cord, which act to inhibit pain-transmitting neurons also located in the spinal dorsal horn. ”
These areas are the areas in which the chemical mechanisms of opioid analgesics will take place
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