Saturday, March 26, 2011

Opioid Analgesics : Endogenous Opioid Peptides

“Endogenous opioid peptides are the naturally occurring ligands for opioid receptors. The term endorphin is used synonymously with endogenous opioid peptides but also refers to a specific endogenous opioid, the Beta-endorphin ”. Opioid analgesics are used for treating chronic pain.
These peptides are produced by the pituitary gland and by the hypothalamus
Opioid peptides are found in the central nervous system mainly in limbic and brainstem areas associated with pain reception, and the certain areas of the spinal cord. Their distribution corresponds to “areas of the human brain where electrical stimulation can relieve pain ”

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